This is a first year Semester one course in biochemistry. It introduces students to the use of units of international system of units, properties of biochemical media (ionic strength, activity of a solute in aqueous solution, ionic strength, osmolarity, absorbance and transmittance Turbidity, temperature), units of concentration (molarity, normality, molarity, percent saturation, percent weight per volume, percent weight per weight, milligram percent and parts per million), Acid/base theory, pH, buffers, physical chemical properties of macromolecules. It ends with thermodynamic principles of biochemistry (laws of thermodynamics, energetic functions of state equilibria, energy conservation and free energy, redox reactions and redox potentials).