The course aims to present basic concepts and principles of radiation biology in radiation therapy. The content will address the theories and principles of tolerance dose, time-dose relationships, fractionation schemes and the relationship to the clinical practice of radiation therapy as well as radiation interaction of body and resultant biophysical events. The course also addresses the practical management of cancer patients, roles of radiotherapy, chemotherapy and hormonal therapy, Radiation Therapy techniques, including external beam radiation and Brach therapy is emphasized
By the end of the course, the student should be able to:1. Describe the epidemiology of cancer2. Define the principles of immunology and histopathology in diagnosis and treatment of cancer3. Define principles of medical and surgical oncology4. Discuss the systemic review of radiosensitive cancers.5. Discuss radiosenstivity and embryogenic effects of radiation6. Describe principles of cellular biology and apply to principles of radiation biology.7. Apply laws and principles of radiation biology to the clinical practice of radiation therapy.8. Distinguish between units of radiation quantities and radiobiologic measures and demonstrate correct usage.9. Identify factors influencing radiobiologic/biophysical events at the cellular and sub-cellular level.10. Describe radiation induced chemical reactions and analyze biologic damage.11. Apply the principles of radiobiology to tumor cell biology and evaluate radiation effects anticipated in the clinical practice of radiation therapy.12. Describe the relationship of time, dose, fractionation, volume and site to radiation effects.13. Describe the use of radiation response modifiers in the clinical practice of radiation therapy.14. Describe the principles of chemotherapy and the influence on biologic effects in combination with radiation therapy.
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