Recent Advances In General Pharmacology, Neuropharmacology, Psychopharmacology, Toxicology And Clinical Trial Design.

Course Code:

PHA 7102

Course Credit Units:

Semester:

Semester 1

Year of Study:

Year 1

Undergraduate or Graduate Level:

Graduate Level

College:

School:

Department:

Course Discipline:

Course Description & Objectives:

Advances in General Pharmacology:Pharmacokinetics, Pharmacokinetic characteristics of Drugs, Pharmacogenetics.
Peripheral, Autonomic, and Central Nervous transmission
Advances in Toxicology; General effects of Drugs and other Chemicals, Characteristics of adverse reactions to drugs and Poisons
Drug Discovery and Development; Pre-clinical Studies, Clinical Trials: designing, ethics, meta-analysis and Drug registration

Central Neurotransmitters and their Pathway: Doperminergic, Cholinergic, 5HT, Noradrenaline Pathways, The Basal Ganglia, Reticular formation and other structures significant in the Pathway, Morphine receptors and Related Compound

Syndromes associated with transmission defects and their management; Schizophrenia, Parkinson’s disease, Depression, Alzheimer’s disease, Mania and Hypomania, Guiles de la Tourette’s Syndrome, Anxiety states, Huntington’s disease.

Anticonvulsants and Anxiolytics: Benzodiazipines, Barbiturates, Newer drugs in this group like Baspirone and others

Learning Outcomes:

At the end of the course students should be able to:

Discuss recent advances in mechanisms of drug action, metabolism and disposition.
Describe the autonomic and central nervous receptors, their transmitters and associated pathological lesions.
Discuss the drug development process and design clinical trials.
Describe drug toxicology, Toxikinetics and Toxidynamics.
Discuss the drugs used in mental illness and their mechanism of action.

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